Selegilene is used to treat canine cognitive dysfunction and a type of Cushing's disease caused by a pituitary tumor. Because it belongs to a class of drugs called Monoamine Oxidase Inhibitors (MAO I's) it should not be given with antidepressants such as Prozac. It is available as 5mg tablets. The usual dose for Cushing's disease is 0.45mg/pound by mouth once a day in the morning. The usual dose for canine cognitive dysfunction is 0.2-0.45mg/pound. Do not use in pregnant or nursing animals.
Anipryl (Pfizer Animal Health),Eldepryl (Somerset)
What is this medication used for
Selegiline,also known as L-Deprenyl,is a monoamine oxidase inhibitor (MAOI) used in the treatment of Cushing's disease and canine cognitive dysfunction (senility).
Selegiline is available by prescription as tablets.
How this medicine should be used
Selegiline is FDA approved for the treatment of Cushing's disease in dogs caused by a pituitary tumor. It is also used to treat cognitive dysfunction. The usual starting dose for treating Cushing's disease is 0.45 mg/pound given in the morning. If no results within 2 months,may increase to 0.9 mg/pound once a day. If no response within 1 month of the increased dose,reevaluate the patient. The dose for Canine Cognitive Dysfunction is 0.2-0.45 mg/pound. It may take up to one month or more to see improvement.
What are the side effects
Side effects when using selegiline may include vomiting,diarrhea,drowsiness,disorientation,hair loss,and shaking.
What special precautions are there
Do not use selegiline in animals allergic to it. Do not use in pregnant or nursing animals. Do not use in dogs who have Cushing's disease caused by other than a pituitary tumor. Do not use selegiline with SSRI antidepressants such as fluoxetine or tricyclic antidepressants such as clomipramine. Do not use with narcotics such as meperidine. Do not use with ephedrine or other MAOIs such as Preventic collars. Use with caution when given with insulin,phenytoin,sulfonamides such as Albon,and phenothiazines such as acepromazine. Always tell your veterinarian and pharmacist what other medications your pet is taking.
In the event of an overdose
Contact your veterinarian or veterinary emergency room. Symptoms of overdose may include salivation,panting,dehydration and death.
How should I store this medication
Keep this medication in the container it came in,tightly closed. Store tablets at room temperature,away from excess heat,light and moisture. Do not store in the bathroom. Throw away any medication that is outdated or no longer needed. Keep this medication out of the reach of children and pets.